An efficient synthesis of tetrahydrofuro[3,2-b]quinolin-2（3H）-ones from α-angelica lactone and 2-aminobenzaldehydes via a tandem Aldol-Michael addition is described. The reactions were carried out using DBU as the base in i-Pr OH at 0 ℃, affording tetrahydrofuro[3,2-b]quinolin-2（3H）-ones in moderate to good yields.
