In view of the importance of β-lactams in the pharmaceutic research field, a series of pyrazoloderi-（vatives） of monocyclic β-lactams 2a2h was prepared from the schiff base 1a1h reactions with phthalo-（ylglycyl） chloride in the presence of triethylamine via \ cycloaddition.The structures and configurations of the（prepared） new monocyclic β-lactams were confirmed by 1H NMR,1H-1H COSY,NOESY,HMBC,HMQC methods.At 7585 ℃,compounds 2a2h were obtained in yields of 19%50% respectively.
Isoxazole derivatives were characterized by broad spectrum of biological activities, but the condensed heterocyclic compounds containing isoxazole were scarcely reported. In this paper, we studied the 1,3-dipolar cycloaddition of p-methoxybenzohydroxamoyl chloride with ethyl sodioacetoacetate to obtain a key intermediate 2. Through compound 2, fifteen novel S-triazolo-1,3,4-thiadiazines(5a-5e), imidazolo-1,3,4-thiadiazoles(9a-9e) and imidazolo-1,3,4-oxadiazoles(10a-10e) containing isoxazole, which have potentially useful biological activities, were synthesized. The structures of the products were confirmed by elemental analyses and spectral analysis. And the characteristic data of IR, 1H NMR and MS were explained reasonably.
