[ Objective ] Study on the effect of perilla seed on blood lipid regulation and peroxidation of Coturnix coturnix with hyperlipidemia. [ Method ] The high-lipid.diet was fed to establish the high lipid model of Coturnix coturnix. The normal control group, high lipid model group, high dose of perilla seed group（2.5 g/kg）, low dose of perilla seed group （0.83 g/kg） were designed to measure the contents of total cholesterol （TC）, three acids glyceride （TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, very low density lipoprotein cholesterol （VLDL-C） and malondialdehyde （MDA）, superoxide dismutase （SOD） activity. [ Result] All the test groups could decrease TC ,TG,LDL-C and MDA content and significantly increase the HDL-C content （p 〈 0.01） and SOD activity（p 〈 0.01 ） in serum. [ Conclusion] Perilla seed has the blood lipid regulation and peroxidation function.
[Objective] The preventive and therapeutic effects of Folium perillae extract （FPE） on hyperlipemia induced by feeding rabbit with high fat forage were observed. [Method] The high fat and cholesterol diet were adopted to create the hyperlipemia model of rabbit. The rabbits were randomly and equally divided into 5 groups which were NC（ normal control）group, HLM （high lipid model） group, LFPE, MFPE and HFPE group （low, middle, high dosage of FPE were 0.17 g/kg, 0.5 g/kg and 1.5 g/kg respectively）. The contents of TC, TG, LDL-C, HDL-C, MDA and the activity of SOD in serum were detected respectively. [ Result] The three FPE groups could decrease the contents of TC, TG, LDL-C, MDA significantly （P〈0.01） compared with these of HLM group, and the contents of HDL-C （P〈0.01） and the activity of SOD （P〈0.05 ） in serum was increased significantly. [Conclusion] FPE could regulate blood-fat and counteract lipid peroxidation.
