Objective To observe the clinical therapeutic effect of knee osteoarthritis treated with electroacupuncture and acupoint injection. Methods Eighty-two cases were randomly divided into observation group and control group, 41 cases in each group. In observation group, electroacupuncture and Danggui (当归 Angelica Sinensis) injection therapy were applied, Dúbí(犊鼻 ST 35), Nèixīyǎn(内膝 眼 EX-LE 4), Liángqiū(梁丘 ST 34), etc. were applied for electroacupuncture, and Liángqiū(梁丘 ST 34), Xuèhǎi(血海 SP 10), Yánglíngquán(阳陵泉 GB 34), etc. were applied for acupoint injection. In control group, electroacupuncture therapy (same as that in observation group) was applied. After two courses treatment, knee function scale and clinical curative effects were compared. Results The improvements of scores of joint pain, range of activity, independent flexion-extension, walking ability, activities of daily living and total scores in two groups after treatment were more signif icant than those before treatment (all P0.05), and the scores in observation group were superior to those in control group(all P0.05). The total effective rate was 92.7% (38/41) in observation group, which was obviously superior to that of 73.2%(30/41) in control group (P0.05). Conclusion The clinical therapeutic effect of knee osteoarthritis treated by electroacupuncture combined with acupoint injection is favorable, and superior to that by electroacupuncture therapy only.