目的:本研究旨在探讨未接受抗骨质疏松治疗的绝经后女性中,瘦体重(Lean Mass, LM)和脂肪量(Fat Mass, FM)对腰椎体积骨密度(Lumbar Spine vBMD)的相对贡献,以期为骨质疏松症的早期诊断和干预提供科学依据。方法:本研究纳入113名绝经后女性(平均年龄63.81 ± 7.34岁),通过双能X线吸收测定法(DXA)评估身体成分(包括LM、FM及其指数),并通过定量CT (QCT)测定腰椎L1~L3的平均骨密度。采用Pearson相关性分析和多重线性回归分析,探讨身体成分参数与腰椎体积骨密度之间的关系。结果:研究发现腰椎体积骨密度与年龄、绝经年限呈显著负相关(p 0.05)。此外,随着骨密度的降低,LM和LMI均显著下降,而FM及其相关指数在三组(正常组、骨质减少组和骨质疏松组)之间无显著差异。结论:瘦体重(LM)是绝经后女性腰椎体积骨密度的重要预测指标。鼓励包括体育活动在内的有利于增强骨骼健康和LM的生活方式,对预防骨质疏松症或肌肉减少症等疾病是十分必要的。Objective: This study aimed to investigate the relative contributions of lean mass (LM) and fat mass (FM) to lumbar spine volumetric bone mineral density (vBMD) in postmenopausal women without anti-osteoporotic treatment, providing scientific evidence for the early diagnosis and intervention of osteoporosis. Methods: A total of 113 postmenopausal women (mean age: 63.81 ± 7.34 years) were included in the study. Body composition parameters, including LM, FM, and their respective indices, were assessed using dual-energy X-ray absorptiometry (DXA). Additionally, the average bone mineral density of the lumbar spine (L1-L3) was measured using quantitative computed tomography (QCT). Pearson correlation analysis and multiple regression analysis were performed to explore the relationships between body composition parameters and lumbar spine vBMD. Results: Lumbar spine vBMD was significantly negatively correlated with age and years since menopause (p 0.05).
