Objective: To investigate levels of depressed mood in patients with Hematological disease. Methods: 41 patients with Hematological diseases were assessed on the SDS and the results were compared with normal control subjects. Results: Patients with Hematological diseases scored higher than the normal control subjects on depressed mood. Female patients had higher scores than the males. When compared to the patients with non-Hematological diseases, there were significant differences in females but not in males. Depressed mood in patients with Hematological diseases endorsed significantly more items on active-somatic and spirit-action than active depressed mood. Conclusion: Medical professions should consider the emotional aspects of patients in order to devise a more comprehensive plan for treatment.