The Securinega alkaloids are a group of compounds isolated from the plants of Securinega,Phyllanthus and Flueggea genera belonging to the Euphorbiaceae family.Most of these compounds exhibit a wide range of biological activities,such as GAB A receptor antagonist,antimalarial and antibacterial activity.Due to the special structural features of Securinega alkaloids, the synthesis strategies for their different structural skeletons are challenging for organic and medicinal chemists.In the review, we will provide an overview of the total synthesis of several Securinega alkaloids and their biological activities.
