With introduction of three heavy manipulations therapy at Dazhui (大椎 GV 14) for unclear enunciation case of acute cerebral infarction, acute attack case of chronic asthmatic bronchitis, amyotrophic lateral sclerosis case of motor neuron disease, ankylosing spondylitis case and chronic fatigue syndrome case, it is confirmed thatDazhui (大椎 GV 14) combined with three heavy manipulations therapy of blood-letting acupuncture, cupping and moxibust-ion has efficacy for external and endogenous wind, promoting and tonifying yang- qi, strengthening the body timely, removing wind and dampness, and relieving the pain and spasm in the clinical practice.