114 patients with genital herpes(GH)divided into three groups at random were treated separately with acyclovir(ACV,0.8g daily orally),interferon(IFN,one million u.in.)and routine external therapy,such as 3% boric acid solution or 0.1% rivanol solution.There was no difference in age and time of onset between these three groups.The effect of drugs was observed at the fourth and eighth days of treatment.A definite effectiveness was manifested in 10(37%)and 21 cases(77.8%)in ACV group,14(48.3%)and 25 cases(86.2%)in IFN group,and only 9(6.9%)and 13cases(22.4%)in routine therapy group.Statistical analysis revealed that ACV and IFN were much mor effective than routine therapy in terms of shortened course and symptoms relieved(P<0.05),but they could not prevent the recurrence of CH.