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国家自然科学基金(81030061): 作品数：4 被引量：9H指数：2; 相关作者：陈忠张翔南刘艳马婧徐阿晶更多>>; 相关机构：浙江大学上海交通大学医学院附属新华医院更多>>; 发文基金：国家自然科学基金国家重点基础研究发展计划更多>>; 相关领域：医药卫生更多>>

小鼠匹鲁卡品癫痫模型潜伏期CA3区后放电阈值及脑电频谱能量的变化: 目的匹鲁卡品(pilocarpine)癫痫模型的潜伏期被认为是其癫痫自发的形成过程。本实验采用小鼠匹鲁卡品模型,研究潜伏期内电刺激诱导的后放电阈值(A DT)以及脑电(EEG)频谱能量的变化。方法ICR小鼠立体定位在右侧...; 徐层林许正浩陈忠

Low frequency stimulation of entorhinal cortex inhibits hippocampal neuronal activities and fast kindling seizures: Objective The entorhinal cortex(EC) is a potential target for low frequency stimulation(LFS,1Hz)treatment of t...; Zheng-hao XUYi WANGAn-Feng TAOCeng-Lin XUMiao-Miao JINKai ZHONGShi-Hong ZHANGZhong CHEN; 关键词：EPILEPSY KINDLING; 文献传递

酸后处理对脑缺血再灌注损伤的保护作用: 目的探讨酸后处理,即在再灌早期给予一段短时间的酸化处理,是否对脑缺血再灌注损伤具有保护作用.方法本实验采用小鼠大脑中动脉栓塞(MCAO)模型和大鼠皮质原代神经元氧糖剥夺(OGD)模型.在再灌早期不同时间点吸入含有20...; 沈哲范彦英张翔南陈忠

The crucial period for focal low frequency stimulation inhibiting the development of amygdala-kindling in rats: ＜正＞Objective To investigate whether there is a crucial period for focal low frequency stimulation（LFS） inhibit...; Yi WANG,Zheng-Hao XU,Yang LIU,Kai ZHONG,Ceng-Lin XU,Wei-Wei HOU,Shi-Hong ZHANG,Zhong CHEN~* Institute of Neuroscience,Department of Pharmacology,College of Pharmaceutical Sciences,School of Medicine, Zhejiang University,Hangzhou 310058,China; 关键词：EPILEPSY; 文献传递

疏水性分形材料PPP对星形胶质细胞的生长与分化的影响: 目的星形胶质细胞对于维持脑功能有着重要作用,它在体内的作用与它的立体结构密切相关.而传统的体外培养的星形胶质细胞失去了它典型的多突触星形状,呈现出扁平的形态.本实验采用由三棕榈酸甘油酯(PPP)合成的具有斥水性的分形材...; 王喆胡薇薇陈忠

Multiple role of minocycline in chronic ischemic cerebral white matter injury: OBJECTIVE The aim of this study was to investi- gate the protection of minocycline in chronic ischemic cerebra...; 马婧; 文献传递

Effect of histaminergic system on brain ischemia: Ischemic stroke is a disease with high mortality and a main leading cause of disability.However,few effective ...; 袁杨; 文献传递

Histamine modulation of acute nociception involves regulation of Nav1.8 in primary afferent neurons in mice: OBJECTIVE To explore the role of histamine in acute pain perception.METHODS We studied the sensitivity to acut...; 于捷Hiroshi Ohtsu; 文献传递

Astrocytes cultured on water-repellent fractal tripalmitin surface demonstrate superior morphology and functions compared with traditional culture substrate: Objective In the CNS,astrocytes play an essential role with their multiple functions and sophisticated structu...; Zhe WANGWei-Wei HUBi-Yuan HONGShan-Shan ZHANGWen-Yun FANGZhong CHEN; 关键词：ASTROCYTE FRACTAL TRIPALMITIN; 文献传递

Rescuing the ischemic brains by inducing ER stress: ＜正＞Aim:The contributions of endoplasmic reticulum（ER） stress in cerebral ischemia/ reperfusion（I/R）-induced in...; Yang YUANJie-qiong GAOZhe SHENJing-ying ZHANGYao SHENWei-wei HUXiang-nan ZHANGZhong CHEN; 关键词：TUNICAMYCIN THAPSIGARGIN EIF2Α; 文献传递

国家自然科学基金(81030061)