Objective Histamine H1 receptor antagonists present epileptogenic activities such as inducing the seizure or p...
Wei-Wei HU~1,Ping HE~1,Hai-Jing YAN~1,Zheng-Hao XU~1,Qi FANG~1,Kai ZHONG~1,Zhong CHEN~(1,2*) 1 Institute of Neuroscience,Department of Pharmacology,School of medicine,Zhejiang University,Hangzhou,310058 China 2 Department of Pharmacology,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058 China
Epilepsy is a common neurological disorder characterized by periodic and unpredictable seizures.Gap junctions have recently been proposed to be involved in the generation,synchronization and maintenance of seizure events.The present review mainly summarizes recent reports concerning the contribution of gap junctions to the pathophysiology of epilepsy,together with the regulation of connexin after clinical and experimental seizure activity.The anticonvulsant effects of gap junction blockers both in vitro and in vivo suggest that the gap junction is a candidate target for the development of antiepileptic drugs.It is also of interest that the roles of neuronal and astrocytic gap junctions in epilepsy have been investigated independently,based on evidence from pharmacological manipulations and connexin-knockout mice.Further studies using more specific manipulations of gap junctions in different cell types and in human epileptic tissue are needed to fully uncover the role of gap junctions in epilepsy.
Objective Astrocytes respond to cerebral ischemia with reactive astrogliosis and participate in the formation ...
Jian-Xiang ZHANG,Wei-Wei HU,Yan-Ying FAN,Ping HE,Zhong CHEN~* Department of Pharmacology,Institute of Neuroscience,College of Pharmaceutical Sciences,Zhejiang University, Hangzhou 310058,China
