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中国博士后科学基金(2012M510361)

作品数:2 被引量:4H指数:2
相关作者:马国需杨峻山张婷婷吴海峰许旭东更多>>
相关机构:哈尔滨商业大学中国医学科学院北京协和医学院海南医学院更多>>
发文基金:中国博士后科学基金国家自然科学基金“重大新药创制”科技重大专项更多>>
相关领域:医药卫生更多>>

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Chemical Constituents with Antihyperlipidemic Activities from Desmodium triquetrum被引量:2
2014年
Objective To study the chemical constituents from Desmodium triquetrum and their antihyperlipidemic activities. Methods The constituents of D. triquetrumwere isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The lipid-lowering effects of the isolates were evaluated in HepG2 cells. Results Nine compounds were obtained from the ethanol extract of D. triquetrum and determined to be 6'-O-cis-p-coumaroyl- 3,5-dihydroxyphenyl-β-D-glucopyranoside (1), tadehaginoside (2), rutin (3), quercetin-3-O-β-D-glucopyranoside (4), quercetin-3-O-β-D-galactopyranoside (5), 6-O-(E)-p-hydroxy-cinnamoyl-β-glucose (6), 6-O-(E)-p-hydroxy-cinnamoyl-α-glucose (7), kaempferol-3-O-β-D-rutinoside (8), and 3-O-β-D-galacopyranosyl (6-1)-α-L- rhamnosyl quercetin (9). Compounds 1 and 2 significantly reduced the intracellular content of total cholesterols and triglycerides. Conclusion Compound 1 is a new phenolic compound and exhibits potent anti-hyperlipidemic activity. Additionally, compounds 6 and 7 are isolated from D. triquetrum for the first time.
Jia-ni WuGuo-xu MaHai-long LiChong-ming WuYin-feng TanTing-ting ZhangFeng ChenPeng GuoXiao-po Zhang
山楝中1个新的链状二萜被引量:2
2014年
目的研究山楝Aphanamixis polystachya茎皮的化学成分。方法采用硅胶柱色谱、Sephadex LH-20、ODS柱色谱及高效液相制备色谱等方法进行分离纯化,根据理化性质及波谱数据鉴定化合物的结构。结果从山楝茎皮95%乙醇提取物中分离得到3个链状二萜,分别鉴定为(2Z,6E,10E)-12,14,15-三羟基-3,7,11,15-四甲基十六碳三烯酸甲酯(1)、melidianolic acid A(2)、陵水暗罗素H(3)。结论化合物1为新化合物,命名为山楝定;化合物2为首次从山楝属植物中分离得到,化合物3为首次从该植物中分离得到。
吴海峰张婷婷吴佳妮马国需张小坡杨峻山许旭东
关键词:ACID
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