乳腺叶状肿瘤(phyllodes tumor of the breast,PTB)作为一种临床少见的纤维上皮性肿瘤,发病率通常小于1%,常见于中年女性。根据组织学特征,PTB可分为良性、恶性和交界性,其中交界性占7%~40%。PTB肿瘤大小一般为4.0 cm~7.0 cm,大于10.0 cm则被定义为巨大叶状肿瘤。本文报告了一例超过20 cm的乳腺巨大交界性叶状肿瘤伴皮肤溃疡及瘤体内囊肿,并结合文献对其诊疗进行探讨。
AIM:To evaluate the clinical efficacy of small-diameter acellular porcine corneal stroma(SAPS)for the treatment of peripheral corneal ulceration(PCU).METHODS:This retrospective clinical study included 18 patients(18 eyes)with PCU between April 2018 and December 2020.All patients had PCU and underwent lamellar keratoplasty with SAPS.Observation indicators included preoperative and postoperative best-corrected visual acuity(BCVA)and transparency of SAPS.The infection control rate in the surgical eye-lesion area was also calculated.RESULTS:Eighteen patients underwent lamellar keratoplasty with SAPS to treat PCU.None of the patients experienced rejection after 6mo(18/18)and 12mo(16/16)of follow-up.The BCVA(0.47±0.30)at the 6mo followup after operation was significantly improved compared with the baseline(0.99±0.80),and the difference was statistically significant(Z=-3.415,P<0.05).The BCVA at the 12mo follow-up after operation was not statistically significant compared to the 6mo(Z=0,P=1).With time,the SAPS graft gradually became transparent.At the 6mo(18/18)and 12mo(16/16)follow-up,none of the patients had recurrent corneal infection.CONCLUSION:SAPS is clinically effective in the treatment of PCU,improving the patient’s BCVA and reducing the incidence of rejection after keratoplasty.
